Ethnoveterinary use of southern african plants and scientific evaluation of their medicinal properties. It is active against gram positive and gram negative cocci, some enteric bacteria, mycobacteria and chlamydia. The inhibitors reported here are mimics of the enol intermediate and the effect of substitution on c2 was studied. Medicinal plants used to treat tb in ghana world health. Accordingly, the main aim of this study was to screen a group of ethnobotanically selected malaysian plants for activity against mycobacterium tuberculosis. Medical pharmacology course description our course in medical pharmacology is designed to prepare the student for the clinical study of therapeutics by providing knowledge of the manner in which drugs modify biological function. Antituberculosis potential of some ethnobotanically selected malaysian plants. Pdf in vitro antituberculosis activity of diterpenoids from. Present study reveals that 6benzyladenine ba either alone or in combination with 1naphthalene acetic acid naa. Tuberculosis tb represents one of the top public health concerns worldwide. In mexican traditional medicine 187 plant species are used in the treatment of.
The crystal structures of mycobacterium tuberculosis type ii dehydroquinase in complex. A number of studies have confirmed the benefits of ayurvedic plants with hypoglycemic effects in the management of this disorder. Synthesis and antibacterial activity of nitroarylthiadiazole levofloxacin hybrids. The present study demonstrated that 1 had antimycobacterial effects on mycobacterium tuberculosis h37rv, multidrug and extensively drugresistant clinical isolates with minimum inhibitory concentrations of 158 and 316. Cytotoxicity and antimicrobial activity of selected plant species. Onethird of the worlds population is infected with mycobacterium tuberculosis m. Plants contain numerous biological active compounds, many of which have been shown to have antimicrobial activity. The synthesis of highaffinity reversible competitive inhibitors of mycobacterium tuberculosis type ii dehydroquinase, an essential enzyme in mycobacterium tuberculosis bacteria, is reported. Syntheses of 1, 2, 4 triazole derivatives and their biological activity.
A varying degree of antituberculosis activity from 097% of growth inhibition was observed with the alkylthio series 6af, and the nitroimidazole derivative with a propylthio group 6b and the nitrofuran derivative with a propargylthio group 6e, were the most active compounds mic3. Recently attention has been directed toward the selection and confirmation of plants with antidiabetic potential. Sivakumar and others published antituberculosis activity of commonly used medicinal plants of south india find, read and cite all the research you need on. However, despite being rich in plant diversity, very little attention has been given to the laboratory evaluation and detection of antituberculosis activity in malaysian medicinal plants. Deciphering the antituberculosis activity of plant extracts. The ethanol extract from gml, punica granatum and quercus infectoria was highly efficient in inhibiting bacterial growth, with mic values of 0. Sm costaceae is an indian ornamental plant which has long been used medicinally in traditional systems of medicine. Plants already reported to have antituberculosis activity adhatoda vasica11,12, allium cepa,14 and aloe vera 1517 were selected to test their activity further against mdr strains of m. The plant has been found to possess diverse pharmacological activities. Combination effect of antituberculosis drugs and ethanolic extract. Biological importance of the indole nucleus in recent years. Plants were collected from wild environments located in the surrounding area of hermosillo, sonora, and.
Antituberculosis, evaluation of in vitro antituberculosis activity and cytotoxicity of some 2 5nitro2furyl 01,3,4 thiadiazole derivatives. Design and synthesis of 5alkoxy1,2,4triazolo4,3aquinoline derivatives with anticonvulsant activity. Pdf antitubercular activity and phytochemical screening of. Among the plants used are those with antituberculosis properties. May 2010 491 biological importance of the indole nucleus. Synthesis of triazoleoxazolidinones via a onepot reaction and evaluation of their antimicrobial activity. Bioorganic and medicinal chemistry letters 18, 486848. Antidiabetic activity of aqueous extract of leptospermum. A prodrug approach for improving antituberculosis activity. Plantderived medicines have since been used in traditional medical system for the treatment of numerous. Antituberculosis activity, phytochemical identification of costus. Isorhamnetin 1 is a naturally occurring flavonoid having anticancer and antiinflammatory properties. The result of phytochemical screening of the leaves extracts shows the presence of alkaloid, glycoside, saponin, tannin, flavonoid, steroids, terpenoid and phenol.
The in vitro antitb activity of different solvent partitions of the plant. Pdf medicinal plants offer a hope for developing alternate medicines for the treatment of tuberculosis the present study was done to. Antimycobacterial and cytotoxic activity of selected medicinal plant. Antituberculosis activity of flavonoids from galenia. In vitro antimycobacterial activity of nine medicinal plants. The study was designed to assess whether plant extracts phytochemical dpinitol synergistically combine with antituberculosis drugs and act on mycobacterium smegmatis m. Resazurin microtitre plate assay checker board was performed to analyze. Antimycobacterial activities of selected medicinal plants from zimbabwe against mycobacterium aurum and corynebacterium glutamicum chimponda, t.
Antituberculosis activity of a naturally occurring flavonoid. If you continue browsing the site, you agree to the use of cookies on this website. There are around 60 global species belonging to the genus sesbania which are commonly found to be grown in africa, australia, and asia. May 2010 491 biological importance of the indole nucleus in. Ethnobotanical information on these plants was obtained. The study was conducted to determine the phytochemical composition and antibacterial activity of citrus aurantifolia leaves extracts against clinical isolates of some enteric bacteria of public health importance. Inh also disrupts dna, lipid, carbohydrate, and nicotinamide adenine dinucleotide nad synthesis andor. Plantderived medicines have since been used in traditional medical system for the treatment of numerous ailments. Mukhopadhyay g, kundu s, sarkar a, sarkar p, sengupta r, kumar c. Antituberculosis activity of flavonoids from galenia africana. Bioinformatics opportunities for identification and study of. The highest antituberculosis activity was observed for ent1. Natural products such as plants have been integral part traditional medicine system in ancient such as chinese, ayurvedic and egyptian 1.
The present study was done to evaluate in vitro antitubercular activity of. Natural compounds from mexican medicinal plants as. Anti diabetic medicinal plants used for diabetes mellitus maryam rahimi department of horticultural science, university of zabol, iran abstract diabetes mellitus is a group of metabolic diseases characterized by high blood sugar glucose levels, that result from defects in insulin secretion, or action, or both. There are many traditional medicinal plants possesses antidiabetic activity has been reported day 1998. In this study, medicinal plants were selected from a. The leaves of sesbania grandiflora have been used in local traditional medicine since ancient times. These results also support the general view that, selecting the plants based on ethnobotanical criteria would enhance the probability of finding species with antituberculosis activity.
On the other hand, the medicinal properties of plants have also been. Article full text enhanced pdf format, 422305 bytes. The various menus and pages linked to database files are designed to provide available information to professionals as well as to those who are new to medicinal plants. Antituberculosis potential of some ethnobotanically. Rhizomes are used to treat pneumonia, rheumatism, dropsy, urinary diseases, jaundice, skin diseases and leaves are usedto treat. Antituberculosis activity of flavonoids from galenia africana l. Medicinal plants used to treat tb in ghana sciencedirect. Jun 15, 20 antitb and anti leprotic drugs medicinal chemistry by p. Phytochemical analyses and activity of herbal medicinal plants of north east india for antidiabetic, anticancer and antituberculosis and their docking studies. To evaluate the effect of the flavonoid fraction on humoral response, its influence was tested on sheep erythrocytespecific. Given that these plantderived chemicals are prototypes of potential drugs for diseases, databases connecting the chemical structures and pharmacological activities may facilitate drug development. The antituberculosis activity of methanolic crude extracts of the plants was tested against multidrug resistant mdr clinical isolates of mycobacterium tuberculosis mtb and mtb h37rv using luciferase reporter phage lrp assay. Medicinal plants have been known since ancient times throughout the world as a rich source of therapeutic substances for remediation and prevention of many diseases.
Antituberculosis potential of some ethnobotanically selected. Thus, this would give traditional medicines plants to play an important role in the control of diabetes mellitus ahmad et al. Antimycobacterial activities of selected medicinal plants. A prodrug approach for improving antituberculosis activity of. The unique geographic features of taiwan are attributed to the rich indigenous and endemic plant species in taiwan.
Plants and extracts preparations plants collection. Despite all of the control strategies, tuberculosis tb is still a major cause of death globally and onethird of the worlds population is infected with tb. The information is recorded in plant scientific name, family, part used, route of administration, dose given, method used pharmacological method and references. Given that these plantderived chemicals are prototypes of potential drugs for diseases, databases connecting the chemical structures and pharmacological activities may facilitate. Evaluation of the antimycobacterial activity of crude extracts and. Synthesis and in vitro evaluation of antimycobacterial activity and cytotoxicity of some npiperazinyl quinolone. Classification of antituberculosis herbs for remedial.
The current study was designed to investigate the antimycobacterial activity and cytotoxicity of crude extracts from five selected medicinal plants. Druginduced hepatotoxicity and hepatoprotective medicinal. Medicinal plants offer a hope for developing alternate medicines for the treatment of tb. The structure activity relationship of the isolated naphthoquinones, and commercially available derivatives were also studied. Antibacterial and anticancer activity of ethnomedicinal plants used. Moreover, higher plant extracts have been considered as promising sources of novel antitb leads 7. Major chemical constituents are alkaloids, flavonoids, glycosides, tannin, anthraquinone, steroid, pholobatannins, and terpenoids. Antituberculosis activity of commonly used medicinal. Antituberculosis activity of bioactive compounds from. Antituberculosis activity of extracts of some plants justifies, to a certain extent their ethnomedicinal uses as remedies for symptoms of tuberculosis. European journal of medicinal chemistry 44, 954958. N r n hn n na no n x s nh c u, hc l x l s x n s n r x o.
In vitro antimycobacterial activity of nine medicinal. Ayurvedic plants with antidiabetic potential springerlink. Nine thai plants have activity against this bacteria. There is a growing literature attempting to document the uses of medicinal plants, followed by chemical analysis and bioassay to determine the effectiveness of individual plant species and place the subject on a scientific footing. Pdf in vitro antituberculosis activity of diterpenoids.
The aim was to screen selected south african medicinal plants used to treat tb and related symptoms by traditional healers for antimycobacterial activity. Bioinformatics opportunities for identification and study. Several published reports had described the antimicrobial activity of various crude extracts of plants either in single or in combination 2. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. The medicinal and chemical aspects of naphthoquinones.
Several plants are used locally to treat tbrelated disease. Folk medical uses of lunas lunasia amara blanco by the. Organic extracts were obtained from nine medicinal plants traditionally used by sonoran ethnic groups to treat. The course includes a systematic study of the effects of drugs on different organ systems and. The crystal structures of mycobacterium tuberculosis type ii dehydroquinase. Antituberculosis activity of a naturally occurring. Rhizomes are used to treat pneumonia, rheumatism, dropsy, urinary diseases, jaundice, skin diseases and leaves are usedto treat mental disorders. Antituberculosis activity of the molecular libraries. References to medicinal plants used by ethnic groups are mainly considered as a relevant guideline in the research of natural products. Antimicrobial activity of sesquiterpene lactones isolated. The cold extraction procedure was adopted for preparing the methanolic crude extracts from the four selected medicinal plants.
Antibacterial activity of citrus aurantifolia leaves. Significant antimicrobial, antioxidant, cytotoxic, thrombolytic and membrane stabilizing activity of this herb were reported. The drugs used for tb treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Mechanism of action the antimicrobial activity of inh is selective for mycobacteria, likely due to its ability to inhibit mycolic acid synthesis, which interferes with cell wall synthesis, thereby producing a bactericidal effect.
Pdf anti tuberculosis activities of medicinal plants. Antibacterial activity of citrus aurantifolia leaves extracts. These plants serve as resourceful bank for biologically active phytochemicals. Antidiabetic agents from medicinal plants bentham science. In addition to phytochemical data, there may be value in cataloging genomic or transcriptomic knowledge about medicinal plants. Boerhaavia diffusa is a widely dispersed plant occurring throughout india, the pacific and southern united states. Biochemical studies on the plant methanolic, hexane and aqueous extracts show the presence of the quinoline alkaloid lunacridine to be effective against tropical ulcers 16, antitubercular 14 and antibacterial activity 17,18, graveolinine, 4methoxy2phenylquinoline and kokusagine for antituberculosis activity 19, lunacridine and its. A number of medicinal plants are being suggested for the treatment of tuberculosis after antimycobacterial activity across the globe newton et al, 2000. These three compounds underwent antituberculosis test and all three compounds were active against mycobacterium tuberculosis h 37 ra, with compounds 1 and 3 having inhibitory concentration at 200 gml while compound 2 was at 100 gml. In vitro antituberculosis activity of diterpenoids from the vietnamese medicinal plant croton tonkinensis article pdf available in journal of natural medicines 701. There are many species with potential for antituberculosis drug development. Several plant species were investigated to establish a possible link between their traditional use for chest related symptoms including tuberculosis infection and the occurrence of 7methyljuglone in these plants. Folk medical uses of lunas lunasia amara blanco by the manobo.
Pdf antituberculosis activity of selected medicinal plants against. The results showed that all three plant extracts achieved good. These plants usually delay the diabetic complications and rectify the metabolic abnormalities. Medicinal and therapeutic value of sesbania grandiflora. Sem observations showed that these active plant partitions caused multiple. Rifampicin rifampin is a semisynthetic derivative of rifamycin, an antibiotic produced by streptomyces mediterranei. The synthesized 1,3,4thiadiazoles were screened for antituberculosis activity against mycobacterium tuberculosis. The current paper documents for the first time medicinal plant species used by ghanaian communities to treat tb. Southeast asian medicinal plants as a potential source of. Only 62 out of the 187 plants quoted have been evaluated for antimycobacterial activity bioassays.
In vitro plant propagation and enhanced metabolite production of active metabolites through biotechnological approaches has gained attention in recent years. Antimalarial activity riscoe et al 2005 demonstrated invitro antimalarial. Chemistry and antioxidant activity of plants containing some phenolic compounds. Anti tuberculosis activities of medicinal plants used in the treatment of tuberculosis in hiv patients in nigeria article pdf available in african journal of microbiology research 510. Oct 25, 2016 recently attention has been directed toward the selection and confirmation of plants with antidiabetic potential. Phytochemical and antimicrobial studies of medicinal plant costus speciosus koen. Nine plants were selected based on their traditional use by sonoran ethnic groups for tuberculosis or symptomrelated diseases, such as cough, fever, lack of appetite, and weakness or caquexia table 1. Nov 25, 20 sonoran ethnic groups yaquis, mayos, seris, guarijios, pimas, kikapues and papagos use mainly herbal based preparations as their first line of medicinal treatment. Antituberculosis activity of selected medicinal plants. Over 10 million scientific documents at your fingertips. The search for biologically active extracts based on traditional use of plants is relevant due to the appearance of microbial resistance to many antibiotics and the occurrence of fatal opportunistic infections.
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